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Crystal Mok

cm561@medschl.cam.ac.uk

+44 (0)1223 336786

 

 

My research focuses on the links between obesity, inflammation and metabolic complications.

 

Obesity is a major health problem in modern societies often associated with diabetes, diseases of the heart and liver. Recently, it has been discovered that during obesity, fat depots in which excess energy is stored under healthy conditions become more inflamed with increased numbers of infiltrating immune cells, namely macrophages. My main interest is to study how excessive lipid accumulation in macrophages affects their inflammatory properties and their contribution towards diabetes and obesity. Information on this may give us insights on how obesity leads to metabolic complications and help to identify potential therapeutic targets.

 

Publications:

 

Prieur X, Mok CY, Velagapudi VR, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O’Rahilly S, Sethi JK, Dopazo J, Orešič M, Ricote M, Vidal-Puig A. (2011). Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes 60(3):797-809. Abstract

 

Presentations: 

 

Title of talk: “The role of lipid accumulation in adipose tissue macrophages polarisation and the Metabolic Syndrome”

Presented at: 1st International Conference on ImmunoMetabolism: Molecular and Cellular Immunology, Crete, Greece, 18-23 September 2011

 

Awards:

 

Trainee Travel Award, 1st International Conference on ImmunoMetabolism: Molecular and Cellular Immunology

Best Poster (1st year PhD group), IMS Away Day, 2009

MRC 4-year PhD Scholarship, 2008-2012