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Dr Chong Yew Tan

cyt23@medschl.cam.ac.uk

+44 (0)1223 768629

 

My area of research is on human obesity focusing on the contribution of white adipose tissue to lipid storage and brown adipose tissue to lipid oxidation. In obesity, the imbalance between caloric intake, storage and oxidation results in surplus lipid which contributes to the development of lipotoxicity and metabolic dysfunction. While weight loss does improve metabolic complications, rapid weight loss is often followed by weight regain and gradual weight loss is hampered by poor compliance. As an alternative, lipotoxicity can be ameliorated by improving lipid storage and/or increasing oxidation. Through improved understanding of what governs the fate of lipids we can alter the storage capacity within adipose tissue and/or increase its oxidation as wasteful heat in brown adipose tissue.

 

Publications:

 

1. Tan, C. Y., Ishikawa, K., Virtue, S. and Vidal-Puig, A. (2011), Brown adipose tissue in the treatment of obesity and diabetes: Are we hot enough? Journal of Diabetes Investigation 2: 341–350. 

 

2. Chong Yew Tan and Antonio Vidal-Puig (2008), Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese Bio Soc Trans 36:935–940. Abstract

 

3. C Lagathu, C Christodoulides, C Y Tan, S Virtue, M Laudes, M Campbell, K Ishikawa, F Ortega, F J Tinahones, J-M Fernández-Real, M Orešič, J K Sethi and A Vidal-Puig (2010), Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity, Int J Obes 34:1695–1705. Abstract

 

Funding acknowledgements: