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Dr Guillaume Bidault

gb483@medschl.cam.ac.uk

+44 (0)1223 336786

 

I obtained my PhD in 2013 from the Université Pierre et Marie Curie (UPMC, Paris, France). During my thesis, I studied the pathophysiology of lipodystrophic and premature aging syndromes due to mutations in the LMNA gene on endothelial dysfunction and insulin resistance.

 

I joined the laboratory of Prof. Antonio Vidal-Puig at the end of 2013. My main area of research concerns the modulation of adipose tissue macrophages by their lipidome in the context of obesity and adipose tissue inflammation. Indeed, obesity is a chronic inflammatory disease characterised by adipose tissue infiltration with macrophages contributing to the metabolic and cardiovascular complications of obesity. More specifically, my studies focus on the role of fatty acid elongation and unsaturation on adipose tissue macrophages functional polarisation.

 

Publications:

Guénantin AC, Briand N, Bidault G, Afonso P, Béréziat V, Vatier C, Lascols O, Caron-Debarle M, Capeau J, Vigouroux C. Nuclear envelope-related lipodystrophies. Semin Cell Dev Biol. 2013 Dec 30. PMID: 24384368

 

Vatier C, Bidault G, Briand N, Guénantin AC, Teyssières L, Lascols O, Capeau J, Vigouroux C. What the genetics of lipodystrophy can teach us about insulin resistance and diabetes. Curr Diab Rep. 2013 Dec;13(6):757-67. PMID: 24026869

 

Bidault G, Garcia M, Vantyghem MC, Ducluzeau PH, Morichon R, Thiyagarajah K, Moritz S, Capeau J, Vigouroux C, Béréziat V. Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2162-71. PMID: 23846499

 

Bidault G, Vatier C, Capeau J, Vigouroux C, Béréziat V. LMNA-linked lipodystrophies: from altered fat distribution to cellular alterations. Biochem Soc Trans. 2011 Dec;39(6):1752-7. PMID: 22103520