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TVP Lab Publications & Scientific Writing

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Selected Publications


1. Peirce V, Carobbio S, Vidal-Puig A. (2014). Nature, 510(7503):76-83. PMID: 24899307.

2. Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JJ, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR. (2014). Response to letter regarding article, “Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans”. Circulation,  129(12):e408. PMID: 24664223.

3. Peirce V, Vidal-Puig A. (2014). Regulation of glucose homeostasis by brown adipose tissue. Lancet Diabetes Endocrinol, 1(4):353-60. PMID: 24622420.


4. Roberts LD, West JA, Vidal-Puig A, Griffin JL. (2014). Methods for performing lipodomics in white adipose tissue. Methods Enzymol, 538:211-31. PMID: 24529441.


5. Vidal-Puig A (2014). Adipose tissue expandability, lipotoxicity and the metabolic syndrome. Endocrinol Nutr, 60 Suppl 1:39-43. PMID: 24490226.

6. Paniagua JA, Escandell-Morales JM, Gil-Contreras D, Berral de la Rosa FJ, Romero-Jimenez M, Gómez-Urbano A, Sanchez-Lopez A, Bellido E, Poyato A, Calatayud B, Vidal-Puig AJ. (2014). Central obesity and altered peripheral adipose tissue gene expression characterize the NAFLD patient with insulin resistance: Role of nutrition and insulin challenge. Nutrition, 30(2):177-85. PMID: 24377452.



7. Sanghez V, Razzoli M, Carobbio S, Campbell M, McCallum J, Cero C, Ceresini G, Cabassi A, Govoni P, Franceschini P, de Santis V, Gurney A, Ninkovic I, Parmigiani S, Palanza P, Vidal-Puig A, Bartolomucci A. (2013). Psychosocial stress induces hyperphagia and exacerbates diet-induced insulin resistance and the manifestations of the Metabolic Syndrome. Psychoneuroendocrinology, 38(12):2933-42. PMID: 24060458.



8. Carobbio S, Rosen B, Vidal-Puig A. (2013). Adipogenesis: new insights into brown adipose tissue differentiation. J Mol Endocrinol, 51(3):T75-85. PMID: 24041933.

9. Moreno-Navarrete JM, Escoté X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Frühbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal-Puig A, Fernández-Real JM. (2013). A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. Diabetologia, 56(11):2524-37. PMID: 23963324.



10. Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. (2013). Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes,62(11):3697-708. PMID: 23919961. PMCID:PMC3806615.



11. Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR. (2013). Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans. Circulation, 128(7):702-12. PMID: 23841983.

12. Camacho A, Huang JK, Delint-Ramirez I, Yew Tan C, Fuller M, Lelliott CJ, Vidal-Puig A, Franklin RJ. (2013). Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis. Eur J Neurosci, 38(5):2672-83. PMID: 23763823.


13. Virtue S, Vidal-Puig A. (2013). Assessment of brown adipose tissue function. Front Physiol, 4:128. PMID: 23760815. PMCID: PMC3671177.


14. Dhurandhar NV, Geurts L, Atkinson RL, Casteilla L, Clement K, Gerard P, Vijay-Kumar M, Nam JH, Nieuwdorp M, Trovato G, Sørensen TI, Vidal-Puig A, Cani PD. (2013). Harnessing the beneficial properties of adipogenic microbes for improving human health. Obes Rev, [Epub ahead of print]. PMID: 23663746.


15. Whittle A, Relat-Pardo J, Vidal-Puig A. (2013). Pharmacological strategies for targeting BAT thermogenesis. Trends Pharacol Sci, 34(6):347-55. PMID: 23648356.


16. Whittle A, Vidal-Puig A. (2013). When BAT is lacking. WAT steps up. Cell Res, 23(7):868-9. PMID: 23609798.


17. Villarroya F, Vidal-Puig A. (2013). Beyond the Sympathetic Tone: The New Brown Fat Activators. Cell Metab, 17(5):638-43. PMID: 23583169.


18. Alligier M, Gabert L, Meugnier E, Lambert-Porcheron S, Chanseaume E, Pilleul F, Debard C, Sauvinet V, Morio B, Vidal-Puig A, Vidal H, Laville M. (2013). Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy men. J Clin Endocrinol Metab, 98(2):802-10. PMID: 23284008.


19. Mercader JM, Puiggros M, Segrè AV, Planet E, Sorianello E, Sebastian D, Rodriguez-Cuenca S, Ribas V, Bonàs-Guarch S, Draghici S, Yang C, Mora S, Vidal-Puig A, Dupuis J; DIAGRAM Consortium, Florez JC; MITIN Consortium, Zorzano A, Torrents D. (2012). Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems. PLoS Genet, 8(12):e1003046. PMID: 23236286. PMCID: PMC3516534.


20. Virtue S, Even P, Vidal-Puig A. (2012). Below Thermoneutrality. Changes in Activity Do Not Drive Changes in Total Daily Energy Expenditure between Groups of Mice. Cell Metab, 16(5):665-71. PMID: 23140644.


21. Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. (2012). A New Role for Lipocalin Prostaglandin D Synthase in the Regulation of Brown Adipose Tissue Substrate Utilization. Diabetes, 2012 Aug 24. PMID: 22923471.


22. Bartolomucci A, Parmigiani S, Rodgers RJ, Vidal-Puig A, Allan SE, Siegel V. (2012). The Obese Species: a special issue on obesity and metabolic disorders. Dis Model Mech, 5(5):563-4. PMID: 22915014. PMCID:PMC3424436.


23. Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešič M, Urade Y, Griffin JL, Vidal-Puig A. (2012). Lipocalin Prostaglandin D Synthase and PPARγ2 Coordinate to Regulate Carbohydrate and Lipid Metabolism In Vivo. PLoS One, 2012;7(7):e39512. Epub 2012 Jul 5. PMID: 22792179. PMCID:PMC3390315.


24. Martínez-García C, Izquierdo A, Velagapudi V, Vivas Y, Velasco I, Campbell M, Burling K, Cava F, Ros M, Oresic M, Vidal-Puig A, Medina-Gomez G. (2012). Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model. Dis Model Mech, 5(5):636-48. PMID: 22773754.


25. Camacho A, Rodriguez-Cuenca S, Blount M, Prieur X, Barbarroja N, Fuller M, Hardingham GE, Vidal-Puig A. (2012). Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response: PGC1 beta coordinates endoplasmic reticulum stress response. Exp Neurol, 237(2):396-406. PMID: 22771762.


26. Puddifoot C, Martel MA, Soriano FX, Camacho A, Vidal-Puig A, Wyllie DJ, Hardingham GE. (2012). PGC-1α Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity. J Neurosci, 16;32(20):6995-7000. PMID: 22593067.


27. Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vázquez MJ, Morgan D, Csikasz RI, Gallego R, Rodriguez-Cuenca S, Dale M, Virtue S, Villarroya F, Cannon B, Rahmouni K, López M, Vidal-Puig A. (2012). BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions. Cell, 149(4):871-85. PMID: 22579288.


28. Rajwani A, Ezzat V, Smith J, Yuldasheva NY, Duncan ER, Gage M, Cubbon RM, Kahn MB, Imrie H, Abbas A, Viswambharan H, Aziz A, Sukumar P, Vidal-Puig A, Sethi JK, Xuan S, Shah AM, Grant PJ, Porter KE, Kearney MT, Wheatcroft SB. (2012). Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis. Diabetes, 61(4):915-24. PMID: 22357965.


29. Napolitano A, Miller SR, Murgatroyd PR, Delafont B, Brooke A, Elkhawad M, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ. (2012). Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention. Clin Pharmacol Ther, 91(6):1027-34.. PMID: 22336590.


30. Rodriguez-Cuenca S, Carobbio S, Vidal-Puig A. (2012). Ablation of Pparg2 impairs lipolysis and reveals murine strain differences in lipolytic responses. FASEB J, 26(5):1835-44. PMID: 223109009.


31. Martínez de Morentin PB, Whittle AJ, Fernø J, Nogueiras R, Diéguez C, Vidal-Puig A, López M. (2012). Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase. Diabetes, 61(4):807-17. PMID: 22315316.


32. Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. (2012). Peroxisome proliferator-activated receptor γ-dependent regulation of lipolytic nodes and metabolic flexibility. Moll Cell Biol, 32(8):1555-65. . PMID: 22310664.


33. Whittle AJ, Vidal-Puig A. (2012). NPs – heart hormones that regulate brown fat? J Clin Invest, 122(3):804-7. PMID: 22307322.

34. Mercer JR, Yu E, Figg N, Cheng KK, Prime TA, Griffin JL, Masoodi M, Vidal-Puig A, Murphy MP, Bennett MR. (2011). The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM(+/-)/ApoE(-/-) mice. Free Radic Biol Med, 52(5):841-9. . PMID: 22210379.

35. Vivas Y, Martinez-Garcia C, Izquierdo A, Garcia-Garcia F, Callejas S, Velasco I, Campbell M, Ros M, Dopazo A, Dopazo J, Vidal-Puig A, Medina-Gomez G. (2011). Early Peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass. BMC Med Genomics, 4(1):86. PMID: 22208362.

36. Meneses ME, Camargo A, Perez-Martinez P, Delgado-Lista J, Cruz-Teno C, Jimenez-Gomez Y, Paniagua JA, Gutierrez-Mariscal FM, Tinahones FJ, Vidal-Puig A, Roche HM, Perez-Jimenez F, Malagon MM, Lopez-Miranda J. (2011). Postprandial inflammatory response in adipose tissue of patients with metabolic syndrome after the intake of different dietary models. Mol Nutr Food Red, 55(12):1759-70. PMID: 22144044.


37. Whittle AJ, Vidal-Puig A. (2011). Physiology: Immune cells fuel the fire. Nature, 480(7375):46-7. PMID: 22101432.


38. Götz AA, Vidal-Puig A, Rödel HG, de Angelis MH, Stoeger T. (2011). Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARγ-defective (P465L) mice. Part Fibre Toxicol, 8:28. PMID: 21933390. PMCID: PMC3197489.


39. Skrede S, Fernø J, Vázquez MJ, Fjær S, Pavlin T, Lunder N, Vidal-Puig A, Diéguez C, Berge RK, López M, Steen VM. (2011). Olanzapine, but not aripiprazole, weight independently elevates serum triglycerides and activates lipogenic gene expression in female rats. Int J Neuropsychopharmacol, 19:1-17. PMID: 21854679.


40. Carobbio S, Rodriguez-Cuenca S, Vidal-Puig A. (2011). Origins of metabolic complications in obesity: ectopic fat accumulation. The importance of the qualitative aspect of lipotoxicity. Curr Opin Clin Nutr Metab Care, 14(6):520-6. PMID: 21849895.


41. Virtue S, Vidal-Puig A. (2011). Nothing Iffy about HIF in the Hypothalamus. PLoS Biol, 9(7):e1001116. PMID 21814494. PMCID: PMC3144187.


42. Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED. (2011). PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res, 109(7):783-93. PMID: 21799152. PMCID: PMC3175248.


43. Jassim G, Skrede S, Vázquez MJ, Wergedal H, Vik-Mo AO, Lunder N, Diéguez C, Vidal-Puig A, Berge RK, López M, Steen VM, Fernø J. (2011). Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology (Berl), [Epub ahead of print]. PMID: 21748251.


44. Bengestrate L, Virtue S, Campbell M, Vidal-Puig A, Hadaschik D, Hahn P, Bielke W. (2011). Genome-wide profiling of microRNAs in adipose mesenchymal stem cell differentiation and mouse models of obesity. PLoS One, 6(6):e21305. PMID: 21731698. PMCID: PMC3121761.


45. Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M, Halldorsson BV, Tikkanen E, Mangino M, Hayward C, Song C, Arnold AM, Aulchenko YS, Oostra BA, Campbell H, Cupples LA, Davis KE, Döring A, Eiriksdottir G, Estrada K, Fernández-Real JM, Garcia M, Gieger C, Glazer NL, Guiducci C, Hofman A, Humphries SE, Isomaa B, Jacobs LC, Jula A, Karasik D, Karlsson MK, Khaw KT, Kim LJ, Kivimäki M, Klopp N, Kühnel B, Kuusisto J, Liu Y, Ljunggren O, Lorentzon M, Luben RN, McKnight B, Mellström D, Mitchell BD, Mooser V, Moreno JM, Männistö S, O’Connell JR, Pascoe L, Peltonen L, Peral B, Perola M, Psaty BM, Salomaa V, Savage DB, Semple RK, Skaric-Juric T, Sigurdsson G, Song KS, Spector TD, Syvänen AC, Talmud PJ, Thorleifsson G, Thorsteinsdottir U, Uitterlinden AG, van Duijn CM, Vidal-Puig A, Wild SH, Wright AF, Clegg DJ, Schadt E, Wilson JF, Rudan I, Ripatti S, Borecki IB, Shuldiner AR, Ingelsson E, Jansson JO, Kaplan RC, Gudnason V, Harris TB, Groop L, Kiel DP, Rivadeneira F, Walker M, Barroso I, Vollenweider P, Waeber G, Chambers JC, Kooner JS, Soranzo N, Hirschhorn JN, Stefansson K, Wichmann HE, Ohlsson C, O’Rahilly S, Wareham NJ, Speliotes EK, Fox CS, Laakso M, Loos RJ. (2011). Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet, 43(8):753-60. PMID: 21706003.


46. Fernø J, Varela L, Skrede S, Vázquez MJ, Nogueiras R, Diéguez C, Vidal-Puig A, Steen VM, López M. (2011). Olanzapine-induced hyperphagia and weight gain associate with orexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. PLoS One, 6(6):e20571. PMID: 21695181. PMCID: PMC3113797.


47. Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešič M. (2011). Association of lipodome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol, 9(6):e1000623. PMID: 21666801. PMCID: PMC3110175.


48. Gurung IS, Medina-Gomez G, Kis A, Baker M, Velagapudi V, Neogi SG, Campbell M, Rodriguez-Cuenca S, Lelliott C, McFarlane I, Oresic M, Grace AA, Vidal-Puig A, Huang CL. (2011). Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia. Cardiovasc Res, 92(1):29-38. PMID: 21632884. PMCID: PMC3172981.


49. Whittle AJ, López M, Vidal-Puig A. (2011). Using brown adipose tissue to treat obesity – the central issue. Trends Mod Med, 17(8):405-11. PMID: 21602104.


50. D’Errico I, Salvatore L, Murzilli S, Lo Sasso G, Latorre D, Martelli N, Egorova AV, Polishuck R, Madeyski-Bengtson K, Lelliott C, Vidal-Puig A, Seibel P, Villani G, Moschetta A. (2011). Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) is a metabolic regulator of intestinal epithelial cell fate. Proc Natl Acad Sci U S A, 108(16):6603-8. PMID: 21467224. PMCID: PMC3081029.


51. Blanco Martínez de Morentin P, González CR, Saha AK, Martins L, Diéguez C, Vidal-Puig A, Tena-Sempere M, López M. (2011). Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance. Rev Endocr Metab Disord, 12(3):127-40. PMID: 21347863.


52. Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O’Rahilly S, Sethi JK, Dopazo J, Orešič M, Ricote M, Vidal-Puig A. (2011). Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 60(3):797-809. PMID: 21266330. PMCID: PMC3046840.


53. Johnson F, Mavrogianni A, Ucci M, Vidal-Puig A, Wardle J. (2011). Could increased time spent in a thermal comfort zone contribute to population increases in obesity? Obes Rev, 12(7):543-51. PMID: 21261804.


54. Varela L, Vázquez MJ, Cordido F, Nogueiras R, Vidal-Puig A, Diéguez C, López M. (2011). Ghrelin and lipid metabolism: key partners in energy balance. J Mol Endocrinol, 46(2):R43-63. PMID: 21169422.


55. McLaughlin BL, Wells AC, Virtue S, Vidal-Puig A, Wilkinson TD, Watson CJ, Robertson PA. (2010). Electrical and optical spectroscopy for quantitative screening of hepatic steatosis in donor livers. Phys Med Biol, 55(22):6867-79. PMID: 21048293.


56. López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A. (2010). Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med, 16(9):1001-8. PMID: 20802499. PMCID: PMC2935934.


57. Virtue S, Dale M, Sethi JK, Vidal-Puig A. (2010). LEM-PCR: a method for determining relative transcript isoform proportions using real-time PCR without a standard curve. Genome, 53(8):637-42. PMID: 20725151.


58. Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, Bennett M. (2010). DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res, 107(8):1021-31. PMID: 20705925. PMCID: PMC2982998.


59. Barbarroja N, López-Pedrera R, Mayas MD, García-Fuentes E, Garrido-Sánchez L, Macías-González M, El Bekay R, Vidal-Puig A, Tinahones FJ. (2010). The obese healthy paradox: is inflammation the answer? Biochem J, 430(1):141-9. PMID: 20522023.


60. Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešič M, Sethi JK, Vidal-Puig A. (2010). Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity. Int J Obes (Lond), 34(12):1695-705. PMID: 20514047.


61. Szopa M, Meirhaeghe A, Luan J, Moreno LA, Gonzalez-Gross M, Vidal-Puig A, Cooper C, Hagen R, Amouyel P, Wareham NJ, Loos RJ. (2010). No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits. Am J Clin Nutr, 92(1):252-7. PMID: 20444954.


62. Hagen RM, Rodriguez-Cuenca S, Vidal-Puig A. (2010). An allostatic control of membrane lipid composition by SREBP1. FEBS Lett, 584(12):2689-98. PMID: 20385130.


63. Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C, López M. (2010). Ghrelin effects of neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. FASEB J, 24(8):2670-9. PMID: 20335227. PMCID: 3230529.


64. Fernandez-Real JM, Menendez JA, Moreno-Navarrete JM, Blüher M, Vazquez-Martin A, Vázquez MJ, Ortega F, Diéguez C, Frühbeck G, Ricart W, Vidal-Puig A. (2010). Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance. Diabetes, 59(6):1506-11. PMID: 20299470. PMCID: PMC2874712.


65. Sethi JK, Vidal-Puig A. (2010). Wnt signalling and the control of celluar metabolism. Biochem J, 427(1):1-17. PMID: 20226003.


66. Boiani R, Cinti S, Savage DB, Vidal-Puig A, O’Rahilly S. (2010). Abdominal subcutaneous adipose tissue morphology in a patient with dominant-negative mutation (P467L) in the nuclear receptor peroxisome proliferator -activated receptor-gamma (PPARG) gene. Nutr Metab Cardiovasc Dis, 20(3):e11-2. PMID: 20153617.


67. Virtue S, Vidal-Puig A. (2010). Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome–an allostatic perspective. Biochim Biophys Acta, 1801(3):338-49. PMID: 20056169.


68. Sørensen TI, Virtue S, Vidal-Puig A. (2010). Obesity as a clinical and public health problem: is there a need for a new definition based on lipotoxicity effects? Biochim Biophys Acta, 1801(3):400-4. PMID: 20045743.


69. Vidal-Puig A, Unger RH. (2010). Special issie on lipotoxicity. Biochim Biophys Acta, 1801(3):207-8. PMID: 20045080.


70. Medina-Gómez G, Vidal-Puig A. (2009). [Adipose tissue as a therapeutic target in obesity]. Endocrinol Nutr, 56(8):404-11. PMID: 19959150.


71. Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, McFarlane I, James AM, Smith RA, Murphy MP. (2010). Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med, 48(1):161-72. PMID: 19854266.


72. Medina-Gomez G, Yetukuri L, Velagapudi V, Campbell M, Blount M, Jimenez-Linan M, Ros M, Oresic M, Vidal-Puig A. (2009). Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Dis Model Mech, 2(11-12):582-92. PMID: 19841237. PMCID: PMC2773727.


73. Christodoulides C, Vidal-Puig A. (2010). PPARs and adipocyte function. Mol Cel Endocrinol, 318(1-2):61-8. PMID: 19772894.


74. Parker N, Crichton PG, Vidal-Puig AJ, Brand MD. (2009). Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria. J Bioenerg Biomembr, 41(4):335-42. PMID: 19705265.


75. Singh A, Wirtz M, Parker N, Hogan M, Strahler J, Michailidis G, Schmidt S, Vidal-Puig A, Diano S, Andrews P, Brand MD, Friedman J. (2009). Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels. Proc Natl Acad Sci U S A, 106(31):13100-5. PMID: 19622746. PMCID: PMC2713753.


76. Crichton PG, Parker N, Vidal-Puig AJ, Brand MD. (2009). Not all mitochondrial carrier proteins support permeability transition pore formation: no involvement of uncoupling protein 1. Biosci Rep, 30(3):187-92. PMID: 19622065.


77. Roberts LD, Virtue S, Vidal-Puig A, Nicholls AW, Griffin JL. (2009). Metabolic phenotyping of a model of adipocyte differentiation. Physiol Genomics, 39(2):109-19. PMID: 19602617. PMCID: PMC2765066.


78. Parker N, Vidal-Puig AJ, Azzu V, Brand MD. (2009). Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2. Biochim Biophys Acta, 1787(12):1451-7. PMID: 19539600. PMCID: PMC2741566.


79. Lelliott CJ, Vidal-Puig A. (2009). PGC-1beta: a co-activator that sets the tone for both basal and stress-stimulated mitochondrial activity. Adv Exp Med Biol, 646:133-9. PMID: 19536672.


80. Kis A, Murdoch C, Zhang M, Siva A, Rodriguez-Cuenca S, Carobbio S, Lukasik A, Blount M, O’Rahilly S, Gray SL, Shah AM, Vidal-Puig A. (2009). Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice. Eur J Heart Fail, 11(6):533-41. PMID: 19395708. PMCID: PMC2686026.


81. Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas L. (2009). CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab, 9(4):339-49. PMID: 19356715. PMCID: PMC2804846.


82. Tang J, Tan CY, Oresic M, Vidal-Puig A. (2009). Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Med, 1(3):35. PMID: 19341506. PMCID: PMC2664946.


83. Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, Aburatani H, Taketani S, Lelliott CJ, Vidal-Puig A, Ikeda K. (2009). Coordination of PGV-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med, 15(3):259-66. PMID: 19252502.


84. Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK. (2009). Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. Diabetes, 58(3):609-19. PMID: 19073771. PMCID: PMC2646059.


85. Christodoulides C, Lagathu C, Sethi JK, Vidal-Puig A. (2009). Adipogenesis and WNT signalling. Trends Endocrinol Metab, 20(1):16-24. PMID: 19008118.


86. Sethi JK, Vidal-Puig AJ. (2008). Wnt signalling at the crossroads of nutritional regulation. Biochem J, 416(2):e11-3. PMID: 18990086.


87. Brookes PS, Parker N, Buckingham JA, Vidal-Puig A, Halestrap AP, Gunter TE, Nicholls DG, Bernardi P, Lemasters JJ, Brand MD. (2008). UCPs–unlikely calcium porters. Nat Cell Biol, 10(11):1235-7; author reply 1237-40. PMID: 18978830. PMCID: PMC2691551.


88. Lage R, Diéguez C, Vidal-Puig A, López M. (2008). AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med, 14(12):539-49. PMID: 18977694.


89. Liesa M, Borda-d’Agua B, Medina-Gómez G, Lelliott CJ, Paz JC, Rojo M, Palacín M, Vidal-Puig A, Zorzano A. (2008). Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One, 3(10):e3613. PMID: 18974884. PMCID: PMC2570954.


90. Oresic M, Hänninen VA, Vidal-Puig A. (2008). Lipodomics: a new window to biomedical frontiers. Trends Biotechnol, 26(12):647-52. PMID: 48951641.


91. Slawik M, Vidal-Puig AJ. (2007). Adipose tissue expandability and the metabolic syndrome. Genes Nutr, 2(1):41-5. PMID: 18850138. PMCID: PMC2474894.


92. Virtue S, Vidal-Puig A. (2008). It’s not how fat you are, it’s what you do with it that counts. PLoS Biol, 6(9):e237. PMID: 18816166. PMCID: PMC2553843.


93. Tan CY, Vidal-Puig A. (2008). Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese. Biochem Soc Trans, 36(Pt 5):935-40. PMID: 18793164.


94. López M, Vidal-Puig A. (2008). Brain lipogenesis and regulation of energy metabolism. Curr Opin Clin Metab Care, 11(4):483-90. PMID: 18542011.


95. Vázquez MJ, González CR, Varela L, Lage R, Tovar S, Sangiao-Alvarellos S, Williams LM, Vidal-Puig A, Nogueiras R, López M, Diéguez C. (2008). Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion. Endocrinology, 149(9):4534-43. PMID: 18499762.


96. López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A. (2008). Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab, 7(5):389-99. PMID: 18460330.


97. Barber TM, Hazell M, Christodoulides C, Golding SJ, Alvey C, Burling K, Vidal-Puig A, Groome NP, Wass JA, Franks S, McCarthy MI. (2008). Serum levels of retinol-binding protein 4 and adiponectin in women with polycistic ovary syndrome: associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this condition. J Clin Endocrinol Metab, 93(7):2859-65. PMID: 18445670.


98. Griffin JL, Vidal-Puig A. (2008). Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding? Physiol Genomics, 34(1):1-5. PMID: 18413782.


99. Parker N, Vidal-Puig A, Brand MD. (2008). Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential. Biosci Rep, 28(2):83-8. PMID: 18384278. PMCID: PMC2518262.


100. Nogueiras R, López M, Lage R, Perez-Tilve D, Pfluger P, Mendieta-Zerón H, Sakkou M, Wiedmer P, Benoit SC, Datta R, Dong JZ, Culler M, Sleeman M, Vidal-Puig A, Horvath T, Treier M, Diéguez C, Tschöp MH. (2008). Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology, 149(6):3009-15. PMID: 18308842. PMCID: PMC2408820.


101. Goodman AO, Murgatroyd PR, Medina-Gomez G, Wood NI, Finer N, Vidal-Puig AJ, Morton AJ, Barker RA. (2008). The metabolic profile of early Huntington’s disease–a combined human and transgenic mouse study. Exp Neurol, 210(2):691-8. PMID: 18284928.


102. Parker N, Affourtit C, Vidal-Puig A, Brand MD. (2008). Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J, 412(1):131-9. PMID: 18251717. PMCID: PMC2474556.


103. Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE, Medina-Gomez G, Kim S, Bock CB, Segvich DM, Solanky B, Deelchand D, Vidal-Puig A, Wareham NJ, Shulman GI, Karpe F, Taylor R, Pederson BA, Roach PJ, O’Rahilly S, DePaoli-Roach AA. (2008). A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscleglycogen content in humans and mice. PLoS Med, 5(1):e27. PMID: 18232732. PMCID: PMC2214798.


104. Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M. (2008). Informatics and computational strategies for the study of lipids. Mol Biosyst, 4(2):121-7. PMID: 18213405.


105. Adams BA, Gray SL, Isaac ER, Bianco AC, Vidal-Puig AJ, Sherwood NM. (2008). Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology, 149(4):1571-80. PMID: 18162530. PMCID: PMC2276722.


106. Burguera B, Agusti A, Arner P, Baltasar A, Barbe F, Barcelo A, Breton I, Cabanes T, Casanueva FF, Couce ME, Dieguez C, Fiol M, Fernandez Real JM, Formiguera X, Fruhbeck G, Garcia Romero M, Garcia Sanz M, Ghigo E, Gomis R, Higa K, Ibarra O, Lacy A, Larrad A, Masmiquel L, Moizé V, Moreno B, Moreiro J, Ricart W, Riesco M, Salinas R, Salvador J, Pi-Sunyer FX, Scopinaro N, Sjostrom L, Pagan A, Pereg V, Sánchez Pernaute A, Torres A, Urgeles JR, Vidal-Puig A, Vidal J, Vila M. (2007). Critical assessment of the current guidelines for the management and treatment of morbidly obese patients. J Endocrinol Invest, 30(10):844-52. PMID: 18075287.


107. Medina-Gomez G, Gray S, Vidal-Puig A. (2007). Adipogenesis and lipoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1). Public Health Nutr, 10(10A):1132-7. PMID: 17903321.


108. Schinner S, Ulgen F, Papewalis C, Schott M, Woelk A, Vidal-Puig A, Scherbaum WA. (2008). Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia, 51(1):147-54. PMID: 17994217.


109. Paniagua JA, de la Sacristana AG, Sánchez E, Romero I, Vidal-Puig A, Berral FJ, Escribano A, Moyano MJ, Peréz-Martinez P, López-Miranda J, Pérez-Jiménez F. (2007). A MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in insulin-resistant subjects. J Am Coll Nutr, 26(5):434-44. PMID: 17914131.


110. Chakravarthy MV, Zhu Y, López M, Yin L, Wozniak DF, Coleman T, Hu Z, Wolfgang M, Vidal-Puig A, Lane MD, Semenkovich CF. (2007). Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest, 117(9):2539-52. PMID: 17694178. PMCID: PMC1937501.


111. López M, Lage R, Tung YC, Challis BG, Varela L, Virtue S, O’Rahilly S, Vidal-Puig A, Diéguez C, Coll AP. (2007). Orexin expression is regulated by alpha-melanocyte-stimulating hormone. J Neuroendocrinol, 19(9):703-7. PMID: 17680885. PMCID: PMC2637479.


112. Gray SL, Vidal-Puig AJ. (2007). Adipose tissue expandability in the maintenance of metabolic homeostasis. Nutr Rev, 65(6 Pt 2):S7-12. PMID: 17605308.


113. Sethi JK, Vidal-Puig AJ. (2007). Targeting fat to prevent diabetes. Cell Metab, 5(5):323-5. PMID: 17488634.


114. Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. (2007). PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet, 3(4):e64. PMID: 17465682. PMCID: PMC1857730.


115. Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso T, Vidal-Puig A, Oresic M. (2007). Bioinformatics strategies for lipodomics analysis: characterization of obesity related hepatic steatosis. BMC Syst Biol, 1:12. PMID: 17408502. PMCID: PMC1839890.


116. Paniagua JA, Gallego de la Sacristana A, Romero I, Vidal-Puig A, Latre JM, Sanchez E, Perez-Martinez P, Lopez-Miranda J, Perez-Jimenez F. (2007). Monounsaturated fat-rich diet prevents central body fat distributed and and decreases postprandial adiponectin expression induced by carbohydrate-rich diet in insulin-resistant subjects. Diabetes Care, 30(7):1717-23. PMID: 17384344.


117. Sethi JK, Vidal-Puig AJ. (2007). Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaption. J Lipid Res, 48(6):1253-62. PMID: 17374880.


118. López M, Lelliott CJ, Vidal-Puig A. (2007). Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake. Bioessays, 29(3):248-61. PMID: 17295284.


119. Wheatcroft SB, Kearney MT, Shah AM, Ezzat VA, Miell JR, Modo M, Williams SC, Cawthorn WP, Medina-Gomez G, Vidal-Puig A, Sethi JK, Crossey PA. (2007). IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes, 56(2):285-94. PMID: 17259371.


120. Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A. (2006). Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function and cardiac performace. PLoS Biol, 4(11):e369. PMID: 17090215. PMCID: PMC1634886.


121. Gray SL, Nora ED, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo GS, Chatterjee VK, O’Rahilly S, Voshol PJ, Cinti S, Vidal-Puig A. (2006). Leptic deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. Diabetes, 55(10):2669-77. PMID: 17003330.


122. Gray SL, Dalla Nora E, Backlund EC, Manieri M, Virtue S, Noland RC, O’Rahilly S, Cortright RN, Cinti S, Cannon B, Vidal-Puig A. (2006). Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome proliferator-activated receptor (P465L PPARgamma) function. Endocrinology, 147(12):5708-14. PMID: 16980437.


123. Oresic M, Vidal-Puig A, Hänninen V. (2006). Metabolomic approaches to phenotype characterization and applications to complex diseases. Expert Rev Diagn, 6(4):575-85. PMID: 16824031.


124. Christodoulides C, Laudes M, Cawthorn WP, Schinner S, Soos M, O’Rahilly S, Sethi JK, Vidal-Puig A. (2006). The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis. J Cell Sci, 119(Pt 12):2613-20. PMID: 16763196.


125. Vidal-Puig A. (2006). [Obesity, MODY and juvenile diabetes: a new diagnostic challenge]. Med Clin (Barc), 126(17):656-7. PMID: 16759566.


126. López M, Lelliott CJ, Tovar S, Kimber W, Gallego R, Virtue S, Blount M, Vázquez MJ, Finer N, Powles TJ, O’Rahilly S, Saha AK, Diéguez C, Vidal-Puig AJ. (2006). Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the vetromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. 55(5):1327-36. PMID: 16644689.


127. Slawik M, Vidal-Puig AJ. (2006). Lipotoxicity, overnutrition and energy metbolism in aging. Ageing Res Rev, 5(2):144-64. PMID: 16630750.


128. Stephens JM, Vidal-Puig AJ. (2006). An update of visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity. Curr Opin Lipidol, 17(2):128-31. PMID: 16531748.


129. Jitrapakdee S, Vidal-Puig A, Wallace JC. (2006). Analplerotic roles of pyruvate carboxylase in mammalian tissues. Cell Mol Life Sci, 63(7-8):843-54. PMID: 16505973.


130. Christodoulides C, Scarda A, Granzotto M, Milan G, Dalla Nora E, Keogh J, De Pergola G, Stirling H, Pannacciulli N, Sethi JK, Federspil G, Vidal-Puig A, Farooqi IS, O’Rahilly S, Vettor R. (2006). WNT10B mutations in human obesity. Diabetologia, 49(4):678-84. PMID: 16477437.


131. Simmgen M, Knauf C, Lopez M, Choudhury AI, Charalambous M, Cantley J, Bedford DC, Claret M, Iglesias MA, Heffron H, Cani PD, Vidal-Puig A, Burcelin R, Withers DJ. (2006). Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice. Diabetologia, 49(3):552-61. PMID: 16404553.


132. Gray SL, Dalla Nora E, Vidal-Puig AJ. (2005). Mouse models of PPAR-gamma deficiency: dissecting PPAR-gamma’s role in metabolic homeostasis. Biochem Soc Trans, 33(Pt 5):1053-8. PMID: 16246044.


133. Sethi JK, Vidal-Puig A. (2005). Visfatin: the missing link between intra-abdominal obesity and diabetes? Trends Mol Med, 11(8):344-7. PMID: 16005682.


134. Lelliott CJ, López M, Curtis RK, Parker N, Laudes M, Yeo G, Jimenez-Liñan M, Grosse J, Saha AK, Wiggins D, Hauton D, Brand MD, O’Rahilly S, Griffin JL, Gibbons GF, Vidal-Puig A. (2005). Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty and acid synthesis in the presence of hepatic steatosis. FASEB J, 19(9):1108-19. PMID: 15985534.


135. Curtis RK, Oresic M, Vidal-Puig A. (2005). Pathways to the analysis of microarray data. Trends Biotechnol, 23(8):429-35. PMID: 15950303.


136. Medina-Gomez G, Vidal-Puig A. (2005). Gateway to the metabolic syndrome. Nat Med, 11(6):602-3. PMID: 15937471.


137. Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O’Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. (2005). The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes, 54(6):1706-16. PMID: 15919792.


138. Jitrapakdee S, Slawik M, Medina-Gomez G, Campbell M, Wallace JC, Sethi JK, O’rahilly S, Vidal-Puig AJ. (2005). The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro. J Biol Chem, 280(29):27466-76. PMID: 15917242.


139. Degawa-Yamauchi M, Moss KA, Bovenkerk JE, Shankar SS, Morrison CL, Lelliott CJ, Vidal-Puig A, Jones R, Considine RV. (2005). Regulation of adiponectin expression in human adipocytes: effects of adiposity, glucocorticoids, and tumor necrosis factor alpha. Obes Res, 13(4):662-9. PMID: 15897474.


140. Semple RK, Meirhaeghe A, Vidal-Puig AJ, Schwabe JW, Wiggins D, Gibbons GF, Gurnell M, Chatterjee VK, O’Rahilly S. (2005). A dominant negative human peroxisome proliferator-activated receptor (PPAR){alpha} is a constitutive transcriptional corepressor and inhibits signaling through all PPAR isoforms. Endocrinology, 146(4):1871-82. PMID: 15661858.


141. Lelliott C, Vidal-Puig AJ. (2004). Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes Relat Metab Disord, 28 Suppl 4:S22-8. PMID: 15592482.


142. Rochford JJ, Semple RK, Laudes M, Boyle KB, Christodoulides C, Mulligan C, Lelliott CJ, Schinner S, Hadaschik D, Mahadevan M, Sethi JK, Vidal-Puig A, O’Rahilly S. (2004). ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis. Mol Cell Biol, 24(22):9863-72. PMID: 15509789. PMCID: PMC525461.


143. Solanes G, Pedraza N, Calvo V, Vidal-Puig A, Lowell BB, Villarroya F. (2005). Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region. Biochem J, 386(Pt 3):505-13. PMID: 15496137. PMCID: PMC1134869.


144. Leonardsson G, Steel JH, Christian M, Pocock V, Milligan S, Bell J, So PW, Medina-Gomez G, Vidal-Puig A, White R, Parker MG. (2004). Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A, 101(22):8437-42. PMID: 15155905. PMCID: PMC420412.


145. Laudes M, Barroso I, Luan J, Soos MA, Yeo G, Meirhaeghe A, Logie L, Vidal-Puig A, Schafer AJ, Wareham NJ, O’Rahilly S. (2004). Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes. Diabetes, 53(3):842-6. PMID: 14988272.


146. Hagen T, Sethi JK, Foxwell N, Vidal-Puig A. (2004). Signalling activity of beta-catenin targeted to different subcellular compartments. Biochem J, 379(Pt 2):471-7. PMID: 14733614. PMCID: PMC1224088.


147. Laudes M, Christodoulides C, Sewter C, Rochford JJ, Considine RV, Sethi JK, Vidal-Puig A, O’Rahilly S. (2004). Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis. J Biol Chem, 279(12):11711-8. PMID: 14701838.


148. Semple RK, Crowley VC, Sewter CP, Laudes M, Christodoulides C, Considine RV, Vidal-Puig A, O’Rahilly S. (2004). Expression of the thermogenic nuclear hormone receptor coactivator PGC-1 alpha is reduced in the adipose tissue of mordidly obese subjects. Int J Obes Relat Metab Disord, 28(1):176-9. PMID: 14557831.


149. Echtay KS, Esteves TC, Pakay JL, Jekabsons MB, Lambert AJ, Portero-Otín M, Pamplona R, Vidal-Puig AJ, Wang S, Roebuck SJ, Brand MD. (2003). A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J, 22(16):4103-10. PMID: 12912909. PMCID: PMC175801.


150. Meirhaeghe A, Crowley V, Lenaghan C, Lelliott C, Green K, Stewart A, Hart K, Schinner S, Sethi JK, Yeo G, Brand MD, Cortright RN, O’Rahilly S, Montague C, Vidal-Puig AJ. (2003). Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. Biochem J, 373(Pt 1):155-65. PMID: 12678921. PMCID: PMC1223480.


151. Savage DB, Tan GD, Acerini CL, Jebb SA, Agostini M, Gurnell M, Williams RL, Umpleby AM, Thomas EL, Bell JD, Dixon AK, Dunne F, Boiani R, Cinti S, Vidal-Puig A, Karpe F, Chatterjee VK, O’Rahilly S. (2003). Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes, 52(4):910-7. PMID: 12663460.


152. Noland RC, Hickner RC, Jimenez-Linan M, Vidal-Puig A, Zheng D, Dohm GL, Cortright RN. (2003). Acute endurance exercise increases skeletal muscle uncoupling protein-3 gene expression in untrained but not trained humans. Metabolism, 52(2):152-8. PMID: 12601624.


153. Sewter C, Blows F, Considine R, Vidal-Puig A, O’Rahilly S. (2002). Differential effects of adiposity on peroxisomal proliferator-activated receptor gamma1 and gamma2 messenger ribonucleic acid expression in human adipocytes. J Clin Endocrinol Metab, 87(9):4203-7. PMID: 12213872.


154. Savage DB, Agostini M, Barroso I, Gurnell M, Luan J, Meirhaeghe A, Harding AH, Ihrke G, Rajanayagam O, Soos MA, George S, Berger D, Thomas EL, Bell JD, Meeran K, Ross RJ, Vidal-Puig A, Wareham NJ, O’Rahilly S, Chatterjee VK, Schafer AJ. (2002). Digenic inheritance of severe insulin resistance in a human pedigree. Nat Genet, 31(4):379-84. PMID: 12118251.


155. Sewter C, Vidal-Puig A. (2002). PPARgamma and the thiazolidinediones: molecular basis for a treatment of ‘Syndrome X’? Diabetes Obes Metab, 4(4):239-48. PMID: 12099972.


156. Roche HM, Noone E, Sewter C, Mc Bennett S, Savage D, Gibney MJ, O’Rahilly S, Vidal-Puig AJ. (2002). Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha. Diabetes, 51(7):2037-44. PMID: 12086931.


157. Hagen T, Vidal-Puig A. (2002). Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45. Biochem Biophys Res Commun, 294(2):324-8. PMID: 12051714.


158. Sewter C, Berger D, Considine RV, Medina G, Rochford J, Ciaraldi T, Henry R, Dohm L, Flier JS, O’Rahilly S, Vidal-Puig AJ. (2002). Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha. Diabetes, 51(4):1035-41. PMID: 11916923.


159. Sewter CP, Blows F, Vidal-Puig A, O’Rahilly S. (2002). Regional differences in the response of human pre-adipocytes to PPARgamma and RXRalpha agonists. Diabetes, 51(3):718-23. PMID: 11872672.


160. Hagen T, Vidal-Puig A. (2002). Mitochondrial uncoupling proteins in human physiology and disease. Minerva Med, 93(1):41-57. PMID: 11850613.


161. Lelliott CJ, Logie L, Sewter CP, Berger D, Jani P, Blows F, O’Rahilly S, Vidal-Puig A. (2002). Lamin expression in human adipose cells in relation to anatomical site and differentiation state. J Clin Endocrinol Metab, 87(2):728-34. PMID: 11836312.


162. Vidal-Puig A, O’Rahilly S. (2001). Resistin: a new link between obesity and insulin resistance? Clin Endocrinol (Oxf), 55(4):437-8. PMID: 11678824.


163. Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, Considine RV, O’Rahilly S. (2001). Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes, 50(10):2199-202. PMID: 11574398.


164. Vidal-Puig A, O’Rahilly S. (2001). Metabolism. Controlling the glucose factory. Nature, 413(6852):125-6. PMID: 11557965.


165. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig A, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. (2001). Uncoupling protein-2 negatively regulates inculin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell, 105(6):745-55. PMID: 11440717.


166. Crowley V, Vidal-Puig A. (2001). Mitochondrial uncoupling proteins (UCPs) and obesity. Nutr Metab Cardiovasc Dis, 11(1):70-5. PMID: 11383327.


167. Huppertz C, Fischer BM, Kim YB, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB. (2001). Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism. J Biol Chem, 276(16):12520-9. PMID: 11278970.


168. Cline GW, Vidal-Puig A, Dufour S, Cadman KS, Lowell BB, Shulman GI. (2001). In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism. J Biol Chem, 276(23):20240-4. PMID: 11274222.


169. Vidal-Puig A. (2000). Uncoupling expectations. Nat Genet, 26(4):387-8. PMID: 11101825.


170. Vidal-Puig A, O’Rahilly S. (2000). Obesity and diabetes: an avalanche of new information. Mol Med Today, 6(6):221-3. PMID: 10939842.


171. Vidal-Puig A, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB. (2000). Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem, 275(21):16258-66. PMID: 10748196.


172. Chung WK, Luke A, Cooper RS, Rotini C, Vidal-Puig A, Rosenbaum M, Chua M, Solanes G, Zheng M, Zhao L, LeDuc C, Eisberg A, Chu F, Murphy E, Schreier M, Aronne L, Caprio S, Kahle B, Gordon D, Leal SM, Goldsmith R, Andreu AL, Bruno C, DiMauro S, Leibel RL et al. (1999). Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis. Diabetes, 48(9):1890-5. PMID: 10480626.


173. Chung WK, Luke A, Cooper RS, Rotini C, Vidal-Puig A, Rosenbaum M, Gordon D, Leal SM, Caprio S, Goldsmith R, Andreu AL, Bruno C, Di Mauro S, Heo M, Lowe WL Jr, Lowell BB, Allison DB, Leibel RL. (1999). The long isoform uncoupling  protein-3 (UCP3L) in human energy homeostasis. Int J Obes Relat Metab Disord, Suppl 6:S49-50. PMID: 10454123.


174. Boss O, Bachman E, Vidal-Puig A, Zhang CY, Peroni O, Lowell BB. (1999). Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1. Biochem Biophys Res Commun, 261(3):870-6. PMID: 10441518.


175. Vidal-Puig A, Rosenbaum M, Considine RC, Leibel RL, Dohm GL, Lowell BB. (1999). Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans. Obes Res, 7(2):133-40. PMID: 10102249.


176. Audi L, Mantzoros CS, Vidal-Puig A, Vargas D, Gussinye M, Carrascosa A. (1998). Leptin in relation to resumption of menses in women with anorexia nervosa. Mol Psychiatry, 3(6):544-7. PMID: 9857982.


177. Ito M, Grujic D, Abel ED, Vidal-Puig A, Susulic VS, Lawitts J, Harper ME, Himms-Hagen J, Strosberg AD, Lowell B. (1998). Mice expressing human but not murine beta3-adregenic receptors under the control of human gene regulatory elements. Diabetes, 47(9):1464-71. PMID: 9726236.


178. Park KS, Ciaraldi TP, Lindgren K, Abrams-Carter L, Mudaliar S, Nikoulina SE, Tufari SR, Veerkamp JH, Vidal-Puig A, Henry RR. (1998). Troglitazone effects on gene expression in human skeletal muscle of type II diabetes involve up-regulation of peroxisome proliferator-activated receptor-gamma. J Clin Endocrinol Metab, 83(8):2830-5. PMID: 9709955.


179. Solanes G, Vidal-Puig A, Grujic D, Flier JS, Lowell BB. (1997). The human uncoupling protein-3. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. J Biol Chem, 272(41):25433-6. PMID: 9325252.


180. Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig A, Flier JS. (1997). Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin. J Biol Chem, 272(32):20230-5. PMID: 9292701.


181. Fajas L, Auboef D, Raspé E, Schoonjans K, Lefebvre AM, Saladin R, Najib J, Laville M, Fruchart JC, Deeb S, Vidal-Puig A, Flier J, Briggs MR, Staels B, Vidal H, Auwerx J. (1997). The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem, 272(30):18779-89. PMID: 9228052.


182. Vidal-Puig A, Bjørbaek C. (1997).  [Molecular genetics of non insulin dependent diabets mellitus]. Med Clin (Barc),  109(3):107-14. PMID: 9289511.


183. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB. (1997). UCP3: an uncoupling protein homologue expressed preferentially  and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun, 235(1):79-82. PMID: 9196039.


184. Vidal-Puig A, Considine RV, Jimenez-Liñan M, Werman A, Pories WJ, Caro JF, Flier JS. (1997). Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest, 99(10):2416-22. PMID: 9153284. PMCID: PMC508081.


185. Vidal-Puig A, Jimenez-Liñan M, Lowell BB, Hamann A, Hu E, Spiegelman B, Flier JS, Moller DE. (1996). Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest, 97(11):2553-61. PMID: 8647948. PMCID: PMC507341.


186. Moller DE, Bjørbaek C, Vidal-Puig A. (1996). Candidate genes for insulin resistance. Diabetes Care, 19(4):396-400. PMID: 8729172.


187. Ludwig DS, Vidal-Puig A, O’Brien RM, Printz RL, Granner DK, Moller DE, Flier JS. (1996). Examination of the phospheonolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab, 81(2):503-6. PMID: 8636258.


188. Hamann A, Mantzoros C, Vidal-Puig A, Flier JS. (1995). Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM). Biochem Biophys Res Commun, 211(3):833-9. PMID: 7598712.


189. Vidal-Puig A, Printz RL, Stratton IM, Granner DK, Moller DE. (1995). Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142–>His substitution. Diabetes, 44(3):340-6. PMID: 7883122.


190. Vidal-Puig A, Faustman DL. (1994). Tolerance to peripheral tissue is transient and maintained by tissue-specific class I expression. Transplant Proc, 26(6):3314-6. PMID: 7998151.


191. Vidal-Puig A, Muñoz-Torres M, Jodar-Gimeno E, García-Calvente C, Lardelli P, Ruiz-Requena ME, Escobar-Jiménez F. (1994). Hyperinsulinemia in polycystic ovary syndrome: relationship to clinical and hormonal factors. Clin Investig, 72(11):853-7. PMID: 7894211.


192. Vidal-Puig A, Muñoz-Torres M, Garcia-Calvente C, Jodar-Gimeno E, Lardelli P, Ruiz-Requena ME, Escobar-Jiménez F. (1994). Reduction of endogenous, ovarian and adrenal androgens with ketoconazole does not alter insulin response in the polycystic ovary syndrome. J Endocrinol Invest, 17(8):647-52. PMID: 7868804.


193. Vidal-Puig A, Moller DE. (1994). Comparative sensitivity of alternative single-strand conformation polymorphism (SSCP) methods. Biotechniques, 17(3):490-2, 494, 496. PMID: 7818902.


194. Vidal-Puig A, Muñoz-Torres M, Jódar-Gimeno E, García-Calvente CJ, Lardelli P, Ruiz-Requena ME, Escobar-Jiménez F. (1994). Ketoconazole therapy: hormonal and clinical effects in non-tumoral hyperandrogenism. Eur J Endocrinol, 130(4):333-8. PMID: 8162160.


195. Vidal-Puig A, Muñoz-Torres M, García Calvente C, Lardelli P, Jódar Gimeno E, Cano M, Ruiz Requena ME, Escobar-Jiménez FE. (1993). [Lipid profile of hyperandrogenic women undergoing treatment with ketoconazole and its relationship with the evolution of the hormone pattern]. Med Clin (Barc), 101(20):766-8. PMID: 8114536.


196. Vidal-Puig A, García-Calvente C, Muñoz Torres M. (1993). [Adrenal androgens: traditionally forgetten hormones. Today, of current importance]. An Med Interna, 10(11):559-64. PMID: 8117874.


197. Vidal-Puig A, Muñoz-Torres M, Escobar-Jiménez F. (1993). [New trends in the definition and diagnostic criteria of polycystic ovary syndrome]. Med Clin (Barc), 100(10):389-93. PMID: 8474284.


198. Vidal-Puig A, Muñoz-Torres M, Escobar-Jiménez F, Ruiz Requena ME, Garcia-Calvente C, Torres-Vela E. (1992). Dehydroepiandrosterone sulfate and other possible influencing factors that modulate sex hormone-binding globulin levels in the hirsute patient. J Steroid Biochem Mol Biol, 42(6):607-11. PMID: 1386249.


199. Muñoz Torres M, Céspedes Mas S, Díaz de Madrid J, Vidal Puig A, Alvarez Cienfuegos E, Escobar Jiménez F. (1990). [Primary hypothyroidism associated with changes in the sella turcica and the hypophyseal function. Description of 5 cases]. Rev Clin Esp, 186(6):274-6. PMID: 2392582.