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Yoshihiro Urade, Ph.D.

Head

Department of Molecular Behavioral Biology

Osaka Bioscience Institute

6-2-4, Furuedai, Suita-shi, Osaka  565-0874 Japan

TEL: 81 6 6872 4851

FAX: 81 6 6872 2841

E-mail: uradey@obi.or.jp

 

URL:  http://www.obi-dept2.com/english/

 

Our department is interested in prostaglandin D2 (PGD2). PGD2 is produced as a major PG in the CNS and acts as an endogenous somnogen. PGD2 is also actively synthesized by mast cells and various immune-related cells and is involved in allergic reaction and inflammation.

 

We study the enzymology of PGD2 production and generated gene-manipulated mice of PGD synthase (PGDS) and PGD2 receptors, analyze the functional abnormalities to elucidate the function of PGD2 in sleep-wake regulation and inflammation.

 

PGD2 is synthesized by either of two isoforms of PGDS: the sleep-related lipocalin-type PGDS (L-PGDS) and the allergic mediator-producing hematopoietic PGDS (H-PGDS). Our department deals with in-depth studies of their structures and functions.

 

For the current year, we elucidated the transcriptional network of sleep/wake regulation to unravel the mechanism of sleep and wakefulness. We promoted the project to develop a portable EEG device used for sleep monitoring at home. Simultaneously, we investigated the involvement of PGD2 in the expansion and repair processes of damaged tissue of patients with Duchenne muscular dystrophy or multiple sclerosis to open a new frontier on therapies geared to delay disease progression in concurrence with the development of new medical treatment.